The natural source for new pancreatic beta cells is an important issue both for understanding the pathogenesis of diabetes, and for possibly curing diabetes by increasing the number of beta cells. Dor et al.1 investigated beta‐cell renewal and regeneration by genetic lineage analysis in mice during physiological growth and after partial pancreatectomy. The data conclusively showed that beta‐cell replication was the only source for new beta cells without contributions from stem cells or other non‐beta cells. This underlines the capacity for (...) beta‐cell self‐renewal and casts doubt that other cell types are able to generate new beta cells in the intact pancreas. BioEssays 26:1156–1159, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

In a letter of 1932, Karl Popper described _Die beiden Grundprobleme der Erkenntnistheorie – The Two Fundamental Problems of the Theory of Knowledge_ – as ‘…a child of crises, above all of …the crisis of physics.’ Finally available in English, it is a major contribution to the philosophy of science, epistemology and twentieth century philosophy generally. The two fundamental problems of knowledge that lie at the centre of the book are the problem of induction, that although we are able to (...) observe only a limited number of particular events, science nevertheless advances unrestricted universal statements; and the problem of demarcation, which asks for a separating line between empirical science and non-science. Popper seeks to solve these two basic problems with his celebrated theory of falsifiability, arguing that the inferences made in science are not inductive but deductive; science does not start with observations and proceed to generalise them but with problems, which it attacks with bold conjectures. _The Two Fundamental Problems of the Theory of Knowledge_ is essential reading for anyone interested in Karl Popper, in the history and philosophy of science, and in the methods and theories of science itself. (shrink)

There are many different meanings of sustainability and precaution and no evident connection between the new normative concepts and the traditional moral theories. We seek an ethical basis for sustainability and precaution—a common framework that can serve as a means of resolving the conceptual ambiguities of the new normative concepts and the conflicts between new and traditional moral concepts and theories. We employ a systemic approach to analyze the past and possible future extension of ethics and establish an inclusive framework (...) of ethical extension. This framework forms the basis for what we call a systemic ethic. (shrink)

Existing accounts of Foucault’s archaeological methodology have not (a) contextualized the concept properly within the intellectual field of its emergence and (b) explained why it is called ‘archaeology’ and not simply ‘history’. Foucault contributed to the field of ‘history of systems of thought’ in France around 1960 by broadening its scope from the study of scientific and philosophical systems into systems of ‘knowledge’ in a wider sense. For Foucault, the term ‘archaeology’ provided a response to new methodological questions arising from (...) this initiative. Archaeological methodology had already been developed into a distinct comparative approach for the study of linguistic and cultural systems, notably by Dumézil. Foucault redevised archaeological methodology for the post-Hegelian tradition of studying ‘problems’ prevalent in the history of systems of thought. The article thus furnishes the groundwork for a ‘sociological archaeology’ or ‘problem analysis’ that is not particularly dependent on Foucault as a social theorist of power. (shrink)

The recent drastic development of agriculture, together with the growing societal interest in agricultural practices and their consequences, pose a challenge to agricultural science. There is a need for rethinking the general methodology of agricultural research. This paper takes some steps towards developing a systemic research methodology that can meet this challenge – a general self-reflexive methodology that forms a basis for doing holistic or (with a better term) wholeness-oriented research and provides appropriate criteria of scientific quality.From a philosophy of (...) research perspective,science is seen as an interactive learning process with both a cognitive and a social communicative aspect. This means, first of all,that science plays a role in the world that it studies. A science that influences its own subject area, such as agricultural science, is named a systemic science. From this perspective, there is a need to reconsider the role of values in science. Science is not objective in the sense of being value-free.Values play, and ought to play, an important role in science – not only in form of constitutive values such as the norms of good science, but also in the form of contextual values that enter into the very process of science. This goes against the traditional criterion of objectivity. Therefore, reflexive objectivity is suggested as a new criterion for doing good science, along with the criterion of relevance. Reflexive objectivity implies that the communication of science must include the cognitive context, which comprises the societal,intentional, and observational context. Ina ccordance with this, the learning process of systemic research is shown as a self-reflexive cycle that incorporates both an involved actor stance and a detached observer stance. The observer stance forms the basis for scientific communication.To this point, a unitary view of science as a learning process is employed. A second important perspective for a systemic research methodology is the relation between the actual,different, and often quite separate kinds of science. Cross-disciplinary research is hampered by the idea that reductive science is more objective, and hence more scientific, than the less reductive sciences of complex subject areas – and by the opposite idea that reductive science is necessarily reductionistic. Taking reflexive objectivity as a demarcator of good science, an inclusive framework of science can be established. The framework does not take the established division between natural, social, and human science as a primary distinction of science.The major distinction is made between the empirical and normative aspects of science,corresponding to two key cognitive interests.Two general methodological dimensions, the degree of reduction of the research world and the degree of involvement in the research world, are shown to span this framework. The framework can form a basis for transdisciplinary work by way of showing the relation between more and less reductive kinds of science and between more detached and more involved kinds of science and exposing the abilities and limitations attendant on these methodological differences. (shrink)

To what degree can language be acquired from linguistic input alone? This question has vexed scholars for millennia and is still a major focus of debate in the cognitive science of language. The complexity of human language has hampered progress because studies of language–especially those involving computational modeling–have only been able to deal with small fragments of our linguistic skills. We suggest that the most recent generation of Large Language Models (LLMs) might finally provide the computational tools to determine empirically (...) how much of the human language ability can be acquired from linguistic experience. LLMs are sophisticated deep learning architectures trained on vast amounts of natural language data, enabling them to perform an impressive range of linguistic tasks. We argue that, despite their clear semantic and pragmatic limitations, LLMs have already demonstrated that human-like grammatical language can be acquired without the need for a built-in grammar. Thus, while there is still much to learn about how humans acquire and use language, LLMs provide full-fledged computational models for cognitive scientists to empirically evaluate just how far statistical learning might take us in explaining the full complexity of human language. (shrink)

The live outdoor webcam seems inseparable from the mid-1990s’ popular proliferation of the Internet. Combining a well-known medium, i.e. the photograph, with a new one, i.e. the Internet, the live outdoor webcam seems in the rear-view mirror to have contributed significantly to the popular perception of the Internet as a globally distended and thus “geographical” medium. Moreover, due to its role in the NASA Triana mission, the never-realised flagship of the Clinton–Gore administration’s Digital Earth project, the live webcam seemed to (...) play an important part in the construction of what leading geographers coined a “virtual geography”—the geography of the Internet, and the networked geography—that sought to establish itself as a new field of study during the late 1990s. In order to substantiate for this interpretation, I would like in the first part of this article to identify a number of basic characteristics of the outdoor webcam and, in the second, to analyse and discuss two papers written by leading scholars in the field; papers which have been important in the assessment of the impact of the Internet and geographical information systems (GIS) before the scientific community as well as policy makers within technological innovation and the public sector. (shrink)

Responds to the reply by L. T. Hoshmand and J. Martin to S. C. Yanchar and K. B. Kristensen's comments on Hoshmand and Martin's proposal for a naturalistic epistemological approach to psychological science. Hoshmand and Martin argue that in Yanchar and Kristensen's stance toward some aspects of their proposal, they have attributed to Hoshmand and Martin a relationship between theory, method, and data that they do not hold. According to Hoshmand and Martin, in making their case Yanchar and (...) Kristensen have objected to empirical means of evaluation, and essentially undermined their own argument. The authors clarify their position by responding to these claims. 2012 APA, all rights reserved). (shrink)

Comments on L. T. Hoshmand & J. Martin's (see record 1995-28533-001) proposal for providing unity in psychological science. Hoshmand and Martin suggest that psychology may derive its own naturalized epistemology by studying and describing the activities in which psychologists are currently engaged, find successful, and how it is that they historically arrived at these practices. While Hoshmand and Martin's notion that an historico-descriptive analysis may be helpful for the study of psychology is not rejected, it is argued that a critical (...) examination of the theoretical bases of psychological research programs, as well as the theoretical assumptions of the historico-descriptive method itself, must precede its employment. (shrink)

"In this edited collection, an international ensemble of scholars examine what contemporary cinema tells us about neoliberal capitalism and cinema, exploring whether filmmakers are able to imagine progressive alternatives under capitalist conditions. Individual contributions discuss filmmaking practices, film distribution, textual characteristics and the reception of films made in different parts of the world. They engage with topics such as class struggle, debt, multiculturalism and the effect of neoliberalism on love and sexual behaviour. Written in accessible, jargon-free language, Contemporary Cinema and (...) Neoliberal Ideology is an essential text for those interested in political filmmaking and the political meanings of films."--Provided by publisher. (shrink)

Atualmente, há um crescente interesse no estudo das sequelas psicológicas em vítimas de queimaduras. Este artigo faz uma revisão da literatura com a finalidade de examinar quais são os danos psicológicos e psiquiátricos mais relevantes apresentados por indivíduos que sofrem acidentes com queimaduras..

This article builds on lessons from Denmark and the Nordic area to offer a novel and comprehensive logic of action within the emerging political economy that may be used to assess the possible new roles that unions can take on. The authors argue that unions are capable of “civilizing” globalization and current forms of governance by becoming responsible for pushing for a governance regime in a new and more egalitarian direction.

IntroductionDrug-related deaths are a major public health challenge. Losing a child to a DRD can be a very stressful life event, which places parents at risk of mental and physical health problems. However, traumatic experiences like losing a child to DRD can paradoxically also lead to positive psychological changes. A mixed-method approach was used to understand the complexity of the phenomenon of post-traumatic growth experienced by parents following a DRD.MethodBy combining data from a survey and interviews, we explored positive growth (...) experiences among Norwegian parents. We conducted descriptive analyses of the sample’s demographic characteristics and mean scores for Post-traumatic Growth Inventory items. Hierarchical multiple regression was used to examine the influence of the ability to perform daily activities, self-efficacy, social support, and symptoms of prolonged grief on the outcome variable of post-traumatic growth. Reflexive thematic analysis was applied to analyze the qualitative data. Finally, we integrated the results of the survey and the interviews.ResultsFor items measuring post-traumatic growth, parents scored highest on the item “I discovered that I’m stronger than I thought I was” and lowest on the item “I am able to do better things with my life.” Self-efficacy and social support had a statistically significant relation with post-traumatic growth. Two themes were generated from the interviews: new perspectives on life and new paths in life. Even though the “New Possibilities” subscale had the lowest mean score for the PTGI-SF, new paths in life were important for many of the interviewed parents.DiscussionParents described traumatic stressors associated with having a child who uses narcotics and hence experienced positive changes even before losing their child. We argue that on an individual level, the consequences of spillover stigma, low self-efficacy, and intrusive rumination can hinder potential post-traumatic growth. On a group level, enhancing network support may increase post-traumatic growth experiences. Hence, parents who have experienced a DRD can benefit from help to activate their social networks and strengthen their self-efficacy. (shrink)

Separate focus on crop fertilization or feeding practices inadequately describes nitrogen (N) loss from mixed dairy farms because of (1) interaction between animal and crop production and between the production system and the manager, and (2) uncertainties of herd N production and crop N utilization. Therefore a systems approach was used to study N turnover and N efficiency on 16 conventional and 14 organic private Danish farms with mixed animal (dairy) and crop production. There were significant differences in N surplus (...) at the farm level (242 kg. N/ha. vs. 124 kg. N/ha. on conventional and organic dairy farms respectively) with a correlation between stocking rate and N surplus. N efficiency was calculated as the output of N in animal products divided by the net N import in fodder, manure and fertilizer. N turnover in herd and individual crops calculated on selected farms showed differences in organic and conventional crop N utilization. This is explained via a discussion of the rationality behind the current way of planning the optimum fertilizer application in conventional agriculture. The concept of marginal N efficiency is insufficient for correcting problems of N loss from dairy farms. Substantial reductions in N loss from conventional mixed dairy farms is probably unlikely without lower production intensity. The concept of mean farm unit N efficiency might be a way to describe the relation between production and N loss to facilitate regulation. This concept is linked to differing goals of agricultural development—i.e. intensification and separation vs. extensification and integration. It is discussed how studies in private farms—using organic farms as selected critical cases—can demonstrate possibilities for balancing production and environmental concern. (shrink)

The article develops an ecopedagogical-philosophical approach to the creative lifeforce kindergarden as a future kindergarden for a nature-friendly and sustainable development. It draws empirically on an action-research project in Klokkergaarden nature- and culture kindergarden in Drammen, Norway. The focus has been on the good meetings between humans, culture and nature through the three main topics that are to mark kindergardens and schools over the next years: life mastery, democracy and sustainable development. The target group is the leadership and employees of (...) kindergardens, and the target is to make concrete what the creative lifeforce kindergarden is, how it shows in practice and how it can be developed as an actor in sustainable community development. (shrink)

This paper examines the relationship between identities and the bicycle as portrayed in films. The analysis finds that taking the viewpoint of the bicycle emancipates the bicycle from being subjected to closure, as the constructionists would have it, and thus articulates the differences with which the bicycle can communicate to its rider. The paper examines the bicycle as depicted in three films: Premium Rush, A Sunday in Hell and Life on Earth. It engages with the concept of ‘interpretative flexibility’ and (...) the development of the bicycle, as examined by Wiebe Bijker and others, and argues that the interpretative flexibility of bicycles does not cease just because the high-wheeler was abandoned and the ‘safety’ bicycle was universally accepted. The fight for the role of the bicycle continues and the bicycle is subject to constant transformations in order to reconstruct it according to human needs. Andrew Feenberg’s modified constructivism is applied to re-examine the technical development of the bicycle, claiming that technology is dependent on specific social structures as well as human agency. The paper argues that just as social structures are negotiable and unfixed at any point in time, the bicycle too is never neutral but remains negotiable and unfixed. Consequently, since the bicycle constantly ‘speaks’ back to the user, there is never closure in the technical development of the bicycle. Drawing on the writings of Bruno Latour and the Deleuzian idea of assemblages, the bicycle and its rider are considered as an organic entity that is constantly forged and un-forged. Understanding the rhetoric of the bicycle machine helps the convergence of a bicycle becoming with becoming a rider, marking the bicycle as equal to its rider. Viewed in this way, the hierarchy of agency collapses and a crystallization emerges out of the rider and bicycle entwinement. (shrink)

In this article Troels Norager discusses the subject of sacrifice in the context of Kierkegaard's Works of Love and Fear and Trembling. The first section argues that contrary to contemporary attempts to turn Kierkegaard into a phenomenologist of love, Kierkegaard should be regarded as a radical Christian thinker who (partly for biographical reasons) deliberately emphasized the necessity of being willing to sacrifice one's most precious love object. The second part deals with Abraham's dilemma in Genesis 22 and argues, critically (...) surveying the intriguing interpretation proposed by Ingolf Dalferth, that no credible solution to this deeply troubling story is to be found. In the final section the author ponders the contemporary significance of Abraham's sacrifice and briefly points to insights from eminent political philosophers like Rawls and Habermas. This leads to the conclusion that theology should finally be taking leave of Abraham by rejecting Abraham as the 'Father of faith' and as a paradigm to be emulated. Instead, theologians and philosophers of religion are called upon to embrace our post-secular modernity without surrendering to the demands of authoritarian religion. (shrink)

Je cherche ici à renouveler la compréhension de l’esthétique merleau-pontienne en lisant les notes de son premier cours au Collège de France, « Le monde sensible et le monde de l’expression ». Ce faisant, on peut voir certains films de Godard comme prolongeant la réflexion du philosophe, éclairer le rapport de Deleuze à la phénoménologie et enfin resituer Merleau-Ponty dans le contexte des pratiques artistiques contemporaines. La portée de cette phénoménologie du mouvement dépasse cependant le cadre de l’esthétique dans la (...) mesure où elle laisse entrevoir une solution au problème du passage du perceptif au conceptuel. (shrink)

The currently burgeoning discussions on ‘socio-ecological resilience’ tend to mask the power relations, contradictions of interest, and inequalities that to a large extent determine how humans utilize the surface of the Earth. Resilience theory has the potential to radically confront such power structures by identifying some of the basic assumptions of economics as the very source of vulnerability, mismanagement, and crises. It has every reason to critically scrutinise the operation of general-purpose money, the global market, and neoliberal ideology. The ultimate (...) implications of resilience theory, in other words, are vastly more radical and subversive than its current proponents imagine. A strategy to enhance socio-ecological resilience would be to distinguish local from global economic scales by employing separate currencies for the two levels. Proponents of resilience theory are advised to engage more respectfully with social science, particularly its understandings of culture and power. Upon doing so, they would find the idea of a bi-centric economy, as sketched in this article, entirely consistent with the fundamental insights of resilience theory. (shrink)

The currently burgeoning discussions on ‘socio-ecological resilience’ tend to mask the power relations, contradictions of interest, and inequalities that to a large extent determine how humans utilize the surface of the Earth. Resilience theory has the potential to radically confront such power structures by identifying some of the basic assumptions of economics as the very source of vulnerability, mismanagement, and crises. It has every reason to critically scrutinise the operation of general-purpose money, the global market, and neoliberal ideology. The ultimate (...) implications of resilience theory, in other words, are vastly more radical and subversive than its current proponents imagine. A strategy to enhance socio-ecological resilience would be to distinguish local from global economic scales by employing separate currencies for the two levels. Proponents of resilience theory are advised to engage more respectfully with social science, particularly its understandings of culture and power. Upon doing so, they would find the idea of a bi-centric economy, as sketched in this article, entirely consistent with the fundamental insights of resilience theory. (shrink)